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Table of Contents

BLOOD COMMENTARIES

BLOOD SPOTLIGHT

In a Blood Spotlight, Stephens reviews the evidence supporting the administration of venetoclax and obinotuzumab for frontline treatment of chronic lymphocytic leukemia and places the combination in the context of other accepted up-front therapies.

REVIEW ARTICLE

Chen and Zhang review the role of eukaryotic initiation factor 2α (eIF2α) in regulating the balance between protein synthesis and iron availability as part of the integrated stress response in erythroid cells.

CLINICAL TRIALS AND OBSERVATIONS

Visco and colleagues report excellent response to eltrombopag in immune thrombocytopenia in the setting of chronic lymphoproliferative disease.

HEMATOPOIESIS AND STEM CELLS

LYMPHOID NEOPLASIA

MYELOID NEOPLASIA

Deletions of chromosome 20q are frequent abnormalities in myelodysplastic syndrome (MDS) and myeloproliferative neoplasms. Stoner et al identify STK4, which encodes Hippo kinase MST1, as the candidate gene from the deleted region that, when deleted, promotes features of MDS and induces myelofibrosis in the presence of JAK2V617F through modulation of inflammatory pathways.

THROMBOSIS AND HEMOSTASIS

Combined factor V and factor VIII deficiency is a rare disorder associated with relatively mild bleeding diathesis. Shao and colleagues elucidate the double role of factor V as both a pro- and anticoagulant protein, demonstrating that decreased factor V may ameliorate factor VIII deficiency through decreasing the level of tissue factor pathway inhibitor.

TRANSPLANTATION

Laberko et al report excellent survival outcomes for patients receiving TCRαβ/CD19-depleted hematopoietic stem cell transplantation (HSCT) for primary immunodeficiencies, demonstrating comparable results with mismatched related and matched unrelated donors.

VASCULAR BIOLOGY

BLOOD WORK

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