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Journal Articles

Retinoic acid synergizes with the unfolded protein response and oxidative stress to induce cell death in FLT3-ITD + AML

Silvia Masciarelli, Ernestina Capuano, Tiziana Ottone, Mariadomenica Divona, Serena Lavorgna, Francesca Liccardo, Martyna Śniegocka, Serena Travaglini, Nelida I. Noguera, Alessandra Picardi, Vincenzo Petrozza, Alessandro Fatica, Luca Tamagnone, Maria Teresa Voso, Francesco Lo Coco, Francesco Fazi
Blood Advances (2019) 3 (24): 4155–4160.
DOI: https://doi.org/10.1182/bloodadvances.2019000540
Published: 2019
Includes: Supplemental data
Journal Articles

Inhibition of the mutated c-KIT kinase in AML1-ETO–positive leukemia cells restores sensitivity to PARP inhibitor

Margaret Nieborowska-Skorska, Elisabeth M. Paietta, Ross L. Levine, Hugo F. Fernandez, Martin S. Tallman, Mark R. Litzow, Tomasz Skorski
Blood Advances (2019) 3 (23): 4050–4054.
DOI: https://doi.org/10.1182/bloodadvances.2019000756
Published: 2019
Includes: Supplemental data
Journal Articles

Patients with FLT3-mutant AML needed to enroll on FLT3-targeted therapeutic clinical trials

Clinical Trials & Observations
Taylor Bucy, John M. Zoscak, III, Motomi Mori, Uma Borate
Blood Advances (2019) 3 (23): 4055–4064.
DOI: https://doi.org/10.1182/bloodadvances.2019000532
Published: 2019
Includes: Supplemental data
Journal Articles

Genomic analyses of flow-sorted Hodgkin Reed-Sternberg cells reveal complementary mechanisms of immune evasion

Kirsty Wienand, Bjoern Chapuy, Chip Stewart, Andrew J. Dunford, David Wu, Jaegil Kim, Atanas Kamburov, Timothy R. Wood, Fathima Zumla Cader, Matthew D. Ducar, Aaron R. Thorner, Anwesha Nag, Alexander T. Heubeck, Michael J. Buonopane, Robert A. Redd, Kamil Bojarczuk, Lee N. Lawton, Philippe Armand, Scott J. Rodig, Jonathan R. Fromm, Gad Getz, Margaret A. Shipp
Blood Advances (2019) 3 (23): 4065–4080.
DOI: https://doi.org/10.1182/bloodadvances.2019001012
Published: 2019
Includes: Supplemental data
Journal Articles

Stem cell mutations can be detected in myeloma patients years before onset of secondary leukemias

Clinical Trials & Observations
Ashwin Sridharan, Carolina D. Schinke, George Georgiev, Mariana Da Silva Ferreira, Victor Thiruthuvanathan, Ian MacArthur, Tushar D. Bhagat, Gaurav S. Choudhary, Srinivas Aluri, Jiahao Chen, Kith Pradhan, Yu Xia, Maya Panjikaran, Gregory Sims, Chirag K. Bhagat, Ryan Bender, Lauryn Keeler, Armin Graber, Christoph Heuck, Frederick A. Fletcher, Daisy Alapat, Niels Weinhold, Sarah K. Johnson, Amittha Wickrema, Bart Barlogie, Gareth J. Morgan, Aditi Shastri, Ulrich Steidl, Britta Will, Amit Verma
Blood Advances (2019) 3 (23): 3962–3967.
DOI: https://doi.org/10.1182/bloodadvances.2019000731
Published: 2019
Includes: Supplemental data
Journal Articles

Clonal dynamics in chronic lymphocytic leukemia

Catherine Gutierrez, Catherine J. Wu
Blood Advances (2019) 3 (22): 3759–3769.
DOI: https://doi.org/10.1182/bloodadvances.2019000367
Published: 2019
Journal Articles

The ParaHox gene Cdx4 induces acute erythroid leukemia in mice

Silvia Thoene, Tamoghna Mandal, Naidu M. Vegi, Leticia Quintanilla-Martinez, Reinhild Rösler, Sebastian Wiese, Klaus H. Metzeler, Tobias Herold, Torsten Haferlach, Konstanze Döhner, Hartmut Döhner, Luisa Schwarzmüller, Ursula Klingmüller, Christian Buske, Vijay P. S. Rawat, Michaela Feuring-Buske
Blood Advances (2019) 3 (22): 3729–3739.
DOI: https://doi.org/10.1182/bloodadvances.2019000761
Published: 2019
Includes: Supplemental data
Journal Articles

LAM-003, a new drug for treatment of tyrosine kinase inhibitor–resistant FLT3-ITD–positive AML

Neil Beeharry, Sean Landrette, Sophia Gayle, Marylens Hernandez, Jeff E. Grotzke, Peter R. Young, Paul Beckett, Xuan Zhang, Bing Z. Carter, Michael Andreeff, Stephanie Halene, Tian Xu, Jonathan Rothberg, Henri Lichenstein
Blood Advances (2019) 3 (22): 3661–3673.
DOI: https://doi.org/10.1182/bloodadvances.2019001068
Published: 2019
Includes: Supplemental data
Journal Articles

Non-del(5q) myelodysplastic syndromes–associated loci detected by SNP-array genome-wide association meta-analysis

Kathy L. McGraw, Chia-Ho Cheng, Y. Ann Chen, Hsin-An Hou, Björn Nilsson, Giulio Genovese, Thomas Cluzeau, Andrea Pellagatti, Bartlomiej P. Przychodzen, Mar Mallo, Leonor Arenillas, Azim Mohamedali, Lionel Adès, David A. Sallman, Eric Padron, Lubomir Sokol, Chimene Moreilhon, Sophie Raynaud, Hwei-Fang Tien, Jacqueline Boultwood, Benjamin L. Ebert, Francesc Sole, Pierre Fenaux, Ghulam J. Mufti, Jaroslaw P. Maciejewski, Peter A. Kanetsky, Alan F. List
Blood Advances (2019) 3 (22): 3579–3589.
DOI: https://doi.org/10.1182/bloodadvances.2019000922
Published: 2019
Includes: Supplemental data
Journal Articles

Thrombotic thrombocytopenic purpura and defective apoptosis due to CASP8/10 mutations: the role of mycophenolate mofetil

Clinical Trials & Observations
F. Fioredda, E. Cappelli, A. Mariani, A. Beccaria, E. Palmisani, A. Grossi, I. Ceccherini, R. Venè, C. Micalizzi, M. Calvillo, F. Pierri, I. Mancini, F. Peyvandi, F. Corsolini, C. Dufour, M. Miano
Blood Advances (2019) 3 (21): 3432–3435.
DOI: https://doi.org/10.1182/bloodadvances.2019000575
Published: 2019
Journal Articles

Human MYD88 L265P is insufficient by itself to drive neoplastic transformation in mature mouse B cells

Tomasz Sewastianik, Maria Luisa Guerrera, Keith Adler, Peter S. Dennis, Kyle Wright, Vignesh Shanmugam, Ying Huang, Helen Tanton, Meng Jiang, Amanda Kofides, Maria G. Demos, Audrey Dalgarno, Neil A. Patel, Anwesha Nag, Geraldine S. Pinkus, Guang Yang, Zachary R. Hunter, Petr Jarolim, Nikhil C. Munshi, Steven P. Treon, Ruben D. Carrasco
Blood Advances (2019) 3 (21): 3360–3374.
DOI: https://doi.org/10.1182/bloodadvances.2019000588
Published: 2019
Includes: Supplemental data
Journal Articles

Blast phenotype and comutations in acute myeloid leukemia with mutated NPM1 influence disease biology and outcome

Emily F. Mason, Robert P. Hasserjian, Nidhi Aggarwal, Adam C. Seegmiller, Olga Pozdnyakova
Blood Advances (2019) 3 (21): 3322–3332.
DOI: https://doi.org/10.1182/bloodadvances.2019000328
Published: 2019
Includes: Supplemental data
Journal Articles

Integrated phosphoproteomics and transcriptional classifiers reveal hidden RAS signaling dynamics in multiple myeloma

Yu-Hsiu T. Lin, Gregory P. Way, Benjamin G. Barwick, Margarette C. Mariano, Makeba Marcoulis, Ian D. Ferguson, Christoph Driessen, Lawrence H. Boise, Casey S. Greene, Arun P. Wiita
Blood Advances (2019) 3 (21): 3214–3227.
DOI: https://doi.org/10.1182/bloodadvances.2019000303
Published: 2019
Includes: Supplemental data
Journal Articles

Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia

Norio Shiba, Kenichi Yoshida, Yusuke Hara, Genki Yamato, Yuichi Shiraishi, Hidemasa Matsuo, Yusuke Okuno, Kenichi Chiba, Hiroko Tanaka, Taeko Kaburagi, Masanobu Takeuchi, Kentaro Ohki, Masashi Sanada, Jun Okubo, Daisuke Tomizawa, Tomohiko Taki, Akira Shimada, Manabu Sotomatsu, Keizo Horibe, Takashi Taga, Souichi Adachi, Akio Tawa, Satoru Miyano, Seishi Ogawa, Yasuhide Hayashi
Blood Advances (2019) 3 (20): 3157–3169.
DOI: https://doi.org/10.1182/bloodadvances.2019000404
Published: 2019
Includes: Supplemental data
Journal Articles

Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets

Jessica I. Hoell, Sebastian Ginzel, Michaela Kuhlen, Andreas Kloetgen, Michael Gombert, Ute Fischer, Daniel Hein, Salih Demir, Martin Stanulla, Martin Schrappe, Udo zur Stadt, Peter Bader, Florian Babor, Friedhelm Schuster, Brigitte Strahm, Julia Alten, Anja Moericke, Gabriele Escherich, Arend von Stackelberg, Ralf Thiele, Alice C. McHardy, Christina Peters, Beat Bornhauser, Jean-Pierre Bourquin, Stefan Krause, Juergen Enczmann, Lüder Hinrich Meyer, Cornelia Eckert, Arndt Borkhardt, Roland Meisel
Blood Advances (2019) 3 (20): 3143–3156.
DOI: https://doi.org/10.1182/bloodadvances.2019000051
Published: 2019
Includes: Supplemental data
Journal Articles

Ring sideroblasts in AML are associated with adverse risk characteristics and have a distinct gene expression pattern

Gerbrig Berger, Mylene Gerritsen, Guoqiang Yi, Theresia N. Koorenhof-Scheele, Leonie I. Kroeze, Marian Stevens-Kroef, Kenichi Yoshida, Yuichi Shiraishi, Eva van den Berg, Hein Schepers, Geert Huls, André B. Mulder, Seishi Ogawa, Joost H. A. Martens, Joop H. Jansen, Edo Vellenga
Blood Advances (2019) 3 (20): 3111–3122.
DOI: https://doi.org/10.1182/bloodadvances.2019000518
Published: 2019
Includes: Supplemental data
Journal Articles

DNA methylation identifies genetically and prognostically distinct subtypes of myelodysplastic syndromes

Brian Reilly, Tiffany N. Tanaka, Dinh Diep, Huwate Yeerna, Pablo Tamayo, Kun Zhang, Rafael Bejar
Blood Advances (2019) 3 (19): 2845–2858.
DOI: https://doi.org/10.1182/bloodadvances.2019000192
Published: 2019
Includes: Supplemental data
Journal Articles

Patients with spontaneous remission of high-risk MDS and AML show persistent preleukemic clonal hematopoiesis

Victoria V. Grunwald, Marcus Hentrich, Xaver Schiel, Annika Dufour, Stephanie Schneider, Michaela Neusser, Marion Subklewe, Michael Fiegl, Wolfgang Hiddemann, Karsten Spiekermann, Maja Rothenberg-Thurley, Klaus H. Metzeler
Blood Advances (2019) 3 (18): 2696–2699.
DOI: https://doi.org/10.1182/bloodadvances.2019000265
Published: 2019
Includes: Supplemental data
Journal Articles

Persistence of skewed X-chromosome inactivation in pre-B acute lymphoblastic leukemia of a female ATRX mutation carrier

Clinical Trials & Observations
Christian P. Bradley, Cai Chen, Karolyn A. Oetjen, Cheng Yan, Reema Panjwani, Sara Hauffe, Katherine R. Calvo, Constance Yuan, Prapti Arvind Patel, Nathan D. Montgomery, Matthew C. Foster, Minoo Battiwalla, A. John Barrett, Richard J. Gibbons, Sawa Ito
Blood Advances (2019) 3 (17): 2627–2631.
DOI: https://doi.org/10.1182/bloodadvances.2019000013
Published: 2019
Journal Articles

Clinical significance of DNA methylation in chronic lymphocytic leukemia patients: results from 3 UK clinical trials

Clinical Trials & Observations
Tomasz K. Wojdacz, Harindra E. Amarasinghe, Latha Kadalayil, Alice Beattie, Jade Forster, Stuart J. Blakemore, Helen Parker, Dean Bryant, Marta Larrayoz, Ruth Clifford, Pauline Robbe, Zadie A. Davis, Monica Else, Dena R. Howard, Basile Stamatopoulos, Andrew J. Steele, Richard Rosenquist, Andrew Collins, Andrew R. Pettitt, Peter Hillmen, Christoph Plass, Anna Schuh, Daniel Catovsky, David G. Oscier, Matthew J. J. Rose-Zerilli, Christopher C. Oakes, Jonathan C. Strefford
Blood Advances (2019) 3 (16): 2474–2481.
DOI: https://doi.org/10.1182/bloodadvances.2019000237
Published: 2019